MRC IEU webapps

About

This is a collection of dashboard-style web applications developed at the MRC Integrative Epidemiology Unit. The IEU website lists other IEU-developed software.

AscRtain

This app was created by Gareth Griffith and highlights some of the functionality of the R Package AscRtain developed by Gibran Hemani and Tom Palmer.

Molecular MR Atlas

An atlas of epigenetic and transcriptomic Mendelian randomization associations by Tom Richardson

Publication

A phenome-wide Mendelian randomization study to elucidate epigenetic and transcriptomic processes which putatively mediate the effect of genetic variants on disease. Tom G Richardson, Genevieve M Leyden, Gibran Hemani, Josine L Min, The GoDMC Consortium, Tom R Gaunt, George Davey Smith and Caroline L Relton. bioRxiv (2019) doi: https://doi.org/10.1101/563379

Tissue MR Atlas

An atlas of tissue-dependent Mendelian randomization associations developed by Tom Richardson.

Publication

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome. Tom G Richardson, Gibran Hemani, Tom R Gaunt, Caroline L Relton and George Davey Smith. Nature Communications (2020)

PRS Atlas

An atlas of polygenic burden associations across the human phenome developed by Tom Richardson.

Publication

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome. Tom G Richardson, Sean Harrison, Gibran Hemani & George Davey Smith. eLife (2019) doi: https://doi.org/10.7554/eLife.43657